Solubility Enhancement of Clozapine by Co-crystals
نویسندگان
چکیده
Cocrystallization of drug with coformers is a promising approach to alter the solid state properties substances like solubility and dissolution. The objective present work was preparation, formulation evaluation clozapine cocrystal by screening various coformers. Clozapine co-crystals were prepared using different benzoic acid, fumaric sodium saccharin acetate. Cocrystals solvent evaporation method drop grinding method. evaluated for saturation solubility, content, dissolution studies, XRD studies DSC analysis.
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ژورنال
عنوان ژورنال: International Journal For Multidisciplinary Research
سال: 2023
ISSN: ['2582-2160']
DOI: https://doi.org/10.36948/ijfmr.2023.v05i03.3158